Yes but script compromises are not attacks against your servers, these are attacks and even hacks into individual scripts, some server security systems will pick these up and some wont.
Some cases its just a matter of looking in the mail queues and seeing a very large amount of queued mail from specific accounts so leading you to investigate that account.
if you have cpanel or directadmin on your server then it is a good idea to goto
http://configserver.com/ and install these on your server (ALL FREE)
ConfigServer Security & Firewall (csf)
ConfigServer ModSecurity Control (cmc)
ConfigServer Explorer (cse)
ConfigServer Mail Queues (cmq)
ConfigServer Mail Manage (cmm)
through SSH using this
cd /usr/src
rm -fv csf.tgz
wget
https://download.configserver.com/csf.tgz
tar -xzf csf.tgz
cd csf
sh install.sh
use the same commands for all the above by just changing the 3 letter code for the script
and if you can afford $60 then also install ConfigServer eXploit Scanner (cXs)
http://configserver.com/cp/cxs.html